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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHL12
All Species:
31.82
Human Site:
Y302
Identified Species:
58.33
UniProt:
Q53G59
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q53G59
NP_067646.1
568
63277
Y302
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Chimpanzee
Pan troglodytes
XP_001149345
684
76181
E411
G
D
A
I
S
S
V
E
R
Y
D
P
Q
T
N
Rhesus Macaque
Macaca mulatta
XP_001094324
702
77633
Y436
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Dog
Lupus familis
XP_537119
568
63260
Y302
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Cat
Felis silvestris
Mouse
Mus musculus
Q8BZM0
568
63228
Y302
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Rat
Rattus norvegicus
Q8R2H4
568
63244
Y302
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518122
290
31726
E30
K
Y
D
P
K
T
Q
E
W
S
F
L
P
S
I
Chicken
Gallus gallus
XP_419251
558
62467
Y292
P
I
D
V
V
E
K
Y
D
P
K
T
Q
E
W
Frog
Xenopus laevis
Q6NRH0
564
63190
Y298
P
I
D
I
V
E
K
Y
D
P
K
T
Q
E
W
Zebra Danio
Brachydanio rerio
Q5U374
564
62914
Y298
P
I
D
I
V
E
K
Y
D
P
K
T
R
E
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUU5
623
68905
E340
G
D
A
I
A
S
V
E
R
F
D
P
Q
T
N
Honey Bee
Apis mellifera
XP_397065
620
68991
E347
G
D
A
I
A
S
V
E
R
F
D
P
N
T
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001180470
684
75689
M412
D
L
V
D
E
A
K
M
F
H
L
R
P
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
37.8
80.9
99.8
N.A.
99.3
99.4
N.A.
50.3
87.1
91.5
89.7
N.A.
39.9
40.4
N.A.
40.6
Protein Similarity:
100
53.6
80.9
100
N.A.
99.8
99.8
N.A.
51
91
96.6
95.2
N.A.
57.9
57.7
N.A.
55.9
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
6.6
100
93.3
86.6
N.A.
6.6
0
N.A.
6.6
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
13.3
100
100
100
N.A.
13.3
6.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
24
0
16
8
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
24
70
8
0
0
0
0
62
0
24
0
0
8
0
% D
% Glu:
0
0
0
0
8
62
0
31
0
0
0
0
0
62
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
16
8
0
0
0
0
% F
% Gly:
24
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
62
0
39
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
8
0
0
0
8
0
70
0
0
0
62
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
0
0
8
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
16
% N
% Pro:
62
0
0
8
0
0
0
0
0
62
0
24
16
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
70
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
24
0
0
8
8
0
8
% R
% Ser:
0
0
0
0
8
24
0
0
0
8
0
0
0
8
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
62
0
24
0
% T
% Val:
0
0
8
47
62
0
24
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
62
% W
% Tyr:
0
8
0
0
0
0
0
62
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _